WS5.2 Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa pulmonary infection
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چکیده
منابع مشابه
Toll-Like Receptor 9 Deficiency Protects Mice against Pseudomonas aeruginosa Lung Infection
Pseudomonas aeruginosa is an opportunistic pathogen involved in nosocomial infections. While a number of studies have demonstrated the roles of TLR2, TLR4 and TLR5 in host defense againt P. aeruginosa infection, the implication of TLR9 in this process has been overlooked. Here, we show that P. aeruginosa DNA stimulates the inflammatory response through TLR9 pathway in both a cell line and prima...
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PURPOSE To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis. METHODS Corneal TLR9 mRNA levels were tested by RT-PCR in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice and compared. The response of B6 mice to CpG DNA, which binds TLR9, was tested after subconjunctival injection of mice with control or CpG DNA; TLR9, IL-1beta, mac...
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Chronic lower respiratory tract infection with Pseudomonas aeruginosa is difficult to treat due to enhanced antibiotic resistance and decreased efficacy of drug delivery to destroyed lung tissue. To determine the potential for restorative immunomodulation therapies, we evaluated the effect of Toll-like receptor 4 (TLR4) stimulation on the host immune response to Pseudomonas infection in mice. W...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2013
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(13)60026-0